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Article

CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients With CYP24A1 Mutations.

The Journal of clinical endocrinology and metabolism - 1 May 2017

Hawkes Colin Patrick, Li Dong, Hakonarson Hakon, Meyers Kevin E, Thummel Kenneth E, Levine Michael A

Abstract excerpt

Context: The P450 enzyme CYP24A1 is the principal inactivator of vitamin D metabolites. Biallelic loss-of-function mutations in CYP24A1 are associated with elevated serum levels of 1,25-dihydroxyvitamin D3 with consequent hypercalcemia and hypercalciuria and represent the most common form of idiopathic infantile hypercalcemia (IIH). Current management strategies for this condition include a low-calcium diet,...

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Identifiers

PMID: 28324001
DOI: 10.1210/jc.2016-4048
PMCID: PMC5443336

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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