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Article

Human 25-hydroxyvitamin D-1alpha-hydroxylase: cloning, mutations, and gene expression.

Pediatric nephrology (Berlin, Germany) - 1 Jul 2000

Portale A A, Miller W L

Abstract excerpt

The rate-limiting, hormonally regulated step in the bioactivation of vitamin D is the 1alpha-hydroxylation of 25-hydroxyvitamin D, which occurs in the kidney and other tissues and is catalyzed by the mitochondrial cytochrome P450 enzyme, P450c1alpha. After many years of effort, the cDNA and gene encoding this enzyme were cloned from mouse, rat, and human tissue in late 1997. The human gene encoding the...

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Identifiers

PMID: 10912530
DOI: 10.1007/pl00009639

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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