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Article

No prognostic value added by vitamin D pathway SNPs to current prognostic system for melanoma survival.

PloS one - 1 Jan 2017

Luo Li, Orlow Irene, Kanetsky Peter A, Thomas Nancy E, Fang Shenying, Lee Jeffrey E, Berwick Marianne, Lee Ji-Hyun

Abstract excerpt

The prognostic improvement attributed to genetic markers over current prognostic system has not been well studied for melanoma. The goal of this study is to evaluate the added prognostic value of Vitamin D Pathway (VitD) SNPs to currently known clinical and demographic factors such as age, sex, Breslow thickness, mitosis and ulceration (CDF). We utilized two large independent well-characterized melanoma studies:...

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Biomarkers, Tumor
Melanoma
Melanoma, Cutaneous Malignant
Proportional Hazards Models
Receptors, Calcitriol

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Vitamin D Deficiency

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PMID: 28323902
DOI: 10.1371/journal.pone.0174234
PMCID: PMC5360355

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