Article
Independent replication of a melanoma subtype gene signature and evaluation of its prognostic value and biological correlates in a population cohort.
Oncotarget - 10 May 2015
Nsengimana Jérémie, Laye Jon, Filia Anastasia, Walker Christy, Jewell Rosalyn, Van den Oord Joost J, Wolter Pascal, Patel Poulam, Sucker Antje, Schadendorf Dirk, Jönsson Göran B, Bishop D Timothy, Newton-Bishop Julia
Abstract excerpt
Development and validation of robust molecular biomarkers has so far been limited in melanoma research. In this paper we used a large population-based cohort to replicate two published gene signatures for melanoma classification. We assessed the signatures prognostic value and explored their biological significance by correlating them with factors known to be associated with survival (vitamin D) or etiological...
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