Article
No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study.
Archives of dermatological research - 1 Jul 2012
Schäfer Annika, Emmert Steffen, Kruppa Jochen, Schubert Steffen, Tzvetkov Mladen, Mössner Rotraut, Reich Kristian, Berking Carola, Volkenandt Matthias, Pföhler Claudia, Schön Michael P, Vogt Thomas, König Inke R, Reichrath Jörg
Abstract excerpt
Melanoma is one of the most aggressive human cancers. The vitamin D system contributes to the pathogenesis and prognosis of malignancies including cutaneous melanoma. An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro. Studies examining associations of polymorphisms in genes coding for vitamin D metabolism-related...
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