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Article

Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B∗35:02 as a risk factor.

Journal of hepatology - 1 Jul 2017

Urban Thomas Jacob, Nicoletti Paola, Chalasani Naga, Serrano José, Stolz Andrew, Daly Ann K, Aithal Guruprasad P, Dillon John, Navarro Victor, Odin Joseph, Barnhart Huiman, Ostrov David, Long Nanye, Cirulli Elizabeth Trilby, Watkins Paul Brent, Fontana Robert John

Abstract excerpt

BACKGROUND & AIMS: Minocycline hepatotoxicity can present with prominent autoimmune features in previously healthy individuals. The aim of this study was to identify genetic determinants of minocycline drug-induced liver injury (DILI) in a well-phenotyped cohort of patients. METHODS: Caucasian patients with minocycline DILI underwent genome-wide genotyping and were compared to unexposed population controls. Human...

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Identifiers

PMID: 28323125
DOI: 10.1016/j.jhep.2017.03.010
PMCID: PMC5634615

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