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Article

Clinical and HLA Associations of Fluoroquinolone-Induced Liver Injury: Results From the Drug-Induced Liver Injury Network.

The American journal of gastroenterology - 1 Jan 2026

Ahmad Jawad, Dellinger Andrew, Nicoletti Paola, Barnhart Huiman X, Ghabril Marwan, Fontana Robert J, Navarro Victor, Choi Gina, Hayashi Paul H, Gu Jiezhun, Kleiner David

Abstract excerpt

INTRODUCTION: Fluoroquinolones (FQ) have a favorable safety profile, but the risk of drug-induced liver injury (DILI) is well described. The aim of this study was to identify clinical features and HLA genetic variants associated with FQ-DILI in a large national registry. METHODS: Analysis of FQ-DILI cases enrolled in DILI Network between 2004 and 2022. HLA class I and II alleles were sequenced by the Illumina...

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Identifiers

PMID: 40207808
DOI: 10.14309/ajg.0000000000003457
PMCID: PMC12353811

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