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Article

Porcine Circovirus Type 2 Suppresses IL-12p40 Induction via Capsid/gC1qR-Mediated MicroRNAs and Signalings.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2018

Du Qian, Wu Xingchen, Wang Tongtong, Yang Xuefeng, Wang Zhenyu, Niu Yingying, Zhao Xiaomin, Liu Shan-Lu, Tong Dewen, Huang Yong

Abstract excerpt

Porcine circovirus (PCV) type 2 (PCV2), an immunosuppression pathogen, is often found to increase the risk of other pathogenic infections. Yet the relative immune mechanisms determining the susceptibility of PCV2-infected animals remain unclear. In this study, we confirmed that PCV2 infection suppressed IL-12p40 expression and host Th1 immune response, leading to a weakened pathogenic clearance upon porcine...

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Source

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Identifiers

PMID: 29858268
DOI: 10.4049/jimmunol.1800250
PMCID: PMC6039236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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