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Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels

6 Sept 2019

Abstract excerpt

cells/ml. Organ building blocks (OBBs) composed of patient-specific-induced pluripotent stem cell-derived organoids offer a pathway to achieving tissues with the requisite cellular density, microarchitecture, and function. However, to date, scant attention has been devoted to their assembly into 3D tissue constructs. Here, we report a biomanufacturing method for assembling hundreds of thousands of these OBBs into...

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PMID: 31523707
DOI: 10.1126/sciadv.aaw2459

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