Article
Fabrication of a matrigel-collagen semi-interpenetrating scaffold for use in dynamic valve interstitial cell culture.
Biomedical materials (Bristol, England) - 24 Jul 2017
Lam Ngoc Thien, Lam Hanh, Sturdivant Nasya M, Balachandran Kartik
Abstract excerpt
The study of heart valve homeostatic and disease mechanisms are often limited by the challenges in simulating the in vivo milieu, where valve cells are surrounded by the extracellular matrix in a three-dimensional (3D) environment and experience multiple dynamic mechanical forces. Type I collagen is typically the most common 3D matrix used to culture valve cells in vitro. Unfortunately, this material has poor...
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