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Targeting AXL Overcomes Adaptive Resistance to KRAS Inhibition in KRAS-Driven Cancer

2026-08-04

Abstract excerpt

Direct KRAS inhibitors have established mutant KRAS as a clinically actionable target, yet adaptive resistance remains a major barrier to durable responses. To identify therapeutically actionable resistance mechanisms, we performed an unbiased in vivo CRISPR activation screen in an autochthonous lung adenocarcinoma model, identifying the receptor tyrosine kinase AXL as a dominant adaptive resistance driver. Pharm...

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Literature Corpus work
4b51ab29-bdab-588d-bc05-6e4ff1d0c52f
DOI
10.64898/2026.08.02.742234
Open publication

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Targeting AXL Overcomes Adaptive Resistance to KRAS Inhibition in KRAS-Driven CancerDOI 10.64898/2026.08.02.742234
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