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Inhibition of spumavirus gene expression by PHF11

17 Jul 2020

Abstract excerpt

The foamy viruses (FV) or spumaviruses are an ancient subfamily of retroviruses that infect a variety of vertebrates. FVs are endemic, but apparently apathogenic, in modern non-human primates. Like other retroviruses, FV replication is inhibited by type-I interferon (IFN). In a previously described screen of IFN-stimulated genes (ISGs), we identified the macaque PHD finger domain protein-11 (PHF11) as an...

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PMID: 32678836
DOI: 10.1371/journal.ppat.1008644

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