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Article

Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis.

Molecular and cellular biology - 15 Jun 2017

Leung Janet Y, Wilson Harper L, Voltzke Kristin J, Williams Lindsay A, Lee Hyo Jin, Wobker Sara E, Kim William Y

Abstract excerpt

Tubulointerstitial fibrosis (TIF) is recognized as a final phenotypic manifestation in the transition from chronic kidney disease (CKD) to end-stage renal disease (ESRD). Here we show that conditional inactivation of Sav1 in the mouse renal epithelium resulted in upregulated expression of profibrotic genes and TIF. Loss of Sav1 induced Stat3 activation and a senescence-associated secretory phenotype (SASP) that...

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Identifiers

PMID: 28320873
DOI: 10.1128/MCB.00565-16
PMCID: PMC5452723

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