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Article

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential.

American journal of physiology. Renal physiology - 1 Nov 2018

Nath Karl A, O'Brien Daniel R, Croatt Anthony J, Grande Joseph P, Ackerman Allan W, Nath Meryl C, Yamada Satsuki, Terzic Andre, Tchkonia Tamara, Kirkland James L, Katusic Zvonimir S

Abstract excerpt

There is no therapy that promotes maturation and functionality of a dialysis arteriovenous fistula (AVF). The search for such therapies largely relies on evaluation of vascular responses and putative therapies in experimental AVFs. We studied an AVF in mice with chronic kidney disease (CKD). We demonstrate numerous stressors in the vein of the AVF-CKD group, including pathological shear, mitogenic, inflammatory,...

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Identifiers

PMID: 30019935
DOI: 10.1152/ajprenal.00308.2018
PMCID: PMC6293292

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