Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.

doi:10.1212/WNL.0000000000004888

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Article

Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.

Neurology - 30 Jan 2018

Fujimaki Motoki, Saiki Shinji, Li Yuanzhe, Kaga Naoko, Taka Hikari, Hatano Taku, Ishikawa Kei-Ichi, Oji Yutaka, Mori Akio, Okuzumi Ayami, Koinuma Takahiro, Ueno Shin-Ichi, Imamichi Yoko, Ueno Takashi, Miura Yoshiki, Funayama Manabu, Hattori Nobutaka

Abstract excerpt

OBJECTIVE: To investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) and controls using liquid chromatography-mass spectrometry. METHODS: Levels of caffeine and its 11 metabolites in serum from 108 patients with PD and 31 age-matched healthy controls were examined by liquid chromatography-mass spectrometry. Mutations in caffeine-associated genes were screened by...

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Identifiers

PMID: 29298852
DOI: 10.1212/WNL.0000000000004888
PMCID: PMC5791797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.