Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caffeine Consumption and Interaction with ADORA2A, CYP1A2 and NOS1 Variants Do Not Influence Age at Onset of Machado-Joseph Disease.

Cerebellum (London, England) - 1 Dec 2024

Martins Ana Carolina, Pinheiro Jordânia Dos Santos, Szinwelski Luciana, Cidade Eduardo Rockenbach, Santin Danilo Fernando, Proença Laura Damke, Araújo Bruna Almeida, Saraiva-Pereira Maria Luiza, Jardim Laura Bannach

Abstract excerpt

BACKGROUND: The age at onset (AO) of Machado-Joseph disease (SCA3/MJD), a disorder due to an expanded CAG repeat (CAGexp) in ATXN3, is quite variable and the role of environmental factors is still unknown. Caffeine was associated with protective effects against other neurodegenerative diseases, and against SCA3/MJD in transgenic mouse models. We aimed to evaluate whether caffeine consumption and its interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Brazil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caffeine

Share to Central Nervous System Stimulants

Share to Cytochrome P-450 CYP1A2

Share to Machado-Joseph Disease

Share to Nitric Oxide Synthase Type I

Share to Receptor, Adenosine A2A

Source

Identifiers

PMID: 38969840
DOI: 10.1007/s12311-024-01717-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caffeine Consumption and Interaction with ADORA2A, CYP1A2 and NOS1 Variants Do Not Influence Age at Onset of Machado-Joseph Disease.PMID 38969840Read ↗

Caffeine consumption and interaction with ADORA2A, CYP1A2 and NOS1 variants do not influence age at onset of Machado-Joseph diseaseSemantic proximity Read ↗

Genome-wide association study identifies genetic factors that modify age at onset in Machado-Joseph diseaseSemantic proximity Read ↗

Genome-wide association study identifies genetic factors that modify age at onset in Machado-Joseph disease.Semantic proximity Read ↗

The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful.Semantic proximity Read ↗

Spinocerebellar ataxia type 3/Machado-Joseph disease: segregation patterns and factors influencing instability of expanded CAG transmissions.Semantic proximity Read ↗

Two novel SNPs in ATXN3 3' UTR may decrease age at onset of SCA3/MJD in Chinese patients.Semantic proximity Read ↗

The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep.Semantic proximity Read ↗

Sequence analysis of 5' regulatory regions of the Machado-Joseph disease gene (ATXN3).Semantic proximity Read ↗

Normal ATXN3 Allele but Not CHIP Polymorphisms Modulates Age at Onset in Machado–Joseph DiseaseSemantic proximity Read ↗

The (CAG)n tract of Machado-Joseph Disease gene (ATXN3): a comparison between DNA and mRNA in patients and controls.Semantic proximity Read ↗

Age is an important independent modifier of SCA3 phenotype severity.Semantic proximity Read ↗

Spinocerebellar ataxia 3 and Machado-Joseph disease: clinical, molecular, and neuropathological features.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.