Oleanolic Acid Acetate Alleviates Cisplatin-Induced Nephrotoxicity Via Inhibition of the Caspase and RIPK Pathways

Abstract excerpt

Cisplatin is a widely used anticancer drug for treating solid tumors, but it is associated with severe side effects, including nephrotoxicity. Various studies have suggested that the nephrotoxicity of cisplatin could be overcome; nonetheless, an effective adjuvant drug has not yet been established. Oleanolic acid acetate (OAA), a triterpenoid isolated from Vigna angularis, is commonly used to treat inflammatory an...

Topics

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• Acute Kidney Injury Research
• Cell death mechanisms and regulation
• Chemotherapy-induced organ toxicity mitigation
• Cholangiocarcinoma and Gallbladder Cancer Studies
• Epigenetics and DNA Methylation
• Flavonoids in Medical Research
• MicroRNA in disease regulation
• Natural product bioactivities and synthesis

Identifiers and source

Literature Corpus work

7071fdb3-d212-5c78-b8a5-28886de53548

DOI

10.20944/preprints202403.0903.v1