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Article

Low-Intensity Training and the C5a Complement Antagonist NOX-D21 Rescue the mdx Phenotype through Modulation of Inflammation.

The American journal of pathology - 1 May 2017

Hyzewicz Janek, Tanihata Jun, Kuraoka Mutsuki, Nitahara-Kasahara Yuko, Beylier Teiva, Ruegg Urs T, Vater Axel, Takeda Shin'ichi

Abstract excerpt

Inflammatory events occurring in dystrophic muscles contribute to the progression of Duchenne muscular dystrophy (DMD). Low-intensity training (LIT) attenuates the phenotype of mdx mice, an animal model for DMD. Therefore, we postulated that LIT could have anti-inflammatory properties. We assessed levels of inflammatory cytokines and infiltrated immune cells in gastrocnemius muscle of mdx mice after LIT. We...

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Source

Identifiers

PMID: 28315675
DOI: 10.1016/j.ajpath.2016.12.019

Genes

CCL2
DMD

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