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Article

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy.

Science translational medicine - 15 Oct 2014

Villalta S Armando, Rosenthal Wendy, Martinez Leonel, Kaur Amanjot, Sparwasser Tim, Tidball James G, Margeta Marta, Spencer Melissa J, Bluestone Jeffrey A

Abstract excerpt

We examined the hypothesis that regulatory T cells (Tregs) modulate muscle injury and inflammation in the mdx mouse model of Duchenne muscular dystrophy (DMD). Although Tregs were largely absent in the muscle of wild-type mice and normal human muscle, they were present in necrotic lesions, displayed an activated phenotype, and showed increased expression of interleukin-10 (IL-10) in dystrophic muscle from mdx...

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Source

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Identifiers

PMID: 25320234
DOI: 10.1126/scitranslmed.3009925
PMCID: PMC4889432

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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