Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects

3 Oct 2022

Abstract excerpt

Treating osteoporosis and associated bone fractures remains challenging for drug development in part due to potential off-target side effects and the requirement for long-term treatment. Here, we identify recombinant adeno-associated virus (rAAV)-mediated gene therapy as a complementary approach to existing osteoporosis therapies, offering long-lasting targeting of multiple targets and/or previously undruggable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to RNA Interference and Gene Delivery
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36184851
DOI: 10.1016/j.ymthe.2022.09.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defectsPMID 36184851Read ↗

Development of AAV-Mediated Gene Therapy Approaches to Treat Skeletal DiseasesSemantic proximity Read ↗

A New Wnt1 Mutant Rat Model of Osteogenesis Imperfecta and Its Application in AAV9-Mediated Gene Therapy.Semantic proximity Read ↗

WNT signaling in bone homeostasis and disease: from human mutations to treatments.Semantic proximity Read ↗

From Stem Cells to Bone: Phenotype Acquisition, Stabilization, and Tissue Engineering in Animal ModelsSemantic proximity Read ↗

The Regulation of Bone Metabolism and Disorders by Wnt Signaling.Semantic proximity Read ↗

The Therapeutic Potential of the Wnt Signaling Pathway in Bone DisordersSemantic proximity Read ↗

SOST/sclerostin, an osteocyte-derived negative regulator of bone formationSemantic proximity Read ↗

MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of boneSemantic proximity Read ↗

AAV-based gene editing of type 1 collagen mutation to treat osteogenesis imperfectaSemantic proximity Read ↗

Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis ImperfectaSemantic proximity Read ↗

MicroRNA levels in bone and blood change during bisphosphonate and teriparatide therapy in an animal model of postmenopausal osteoporosisSemantic proximity Read ↗

Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular densitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.