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Article

Mitral valve endothelial cells with osteogenic differentiation potential.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2011

Wylie-Sears Jill, Aikawa Elena, Levine Robert A, Yang Jeong-Hee, Bischoff Joyce

Abstract excerpt

OBJECTIVE: Cardiac valvular endothelium is unique in its ability to undergo endothelial-to-mesenchymal transformation, a differentiation process that is essential for valve development and has been proposed as mechanism for replenishing the interstitial cells of mature valves. We hypothesized that the valvular endothelium contains endothelial cells that are direct precursors to osteoblastic valvular interstitial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21164078
DOI: 10.1161/ATVBAHA.110.216184
PMCID: PMC3210435

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