Article
Fitness Effect of the Isoniazid Resistance Mutation S315T of the Catalase-Peroxidase Enzyme KatG of Mycobacterium tuberculosis.
Genome biology and evolution - 3 Jul 2025
Bastolla Ugo, Rotkevich Mikhail, Arenas Miguel, Arrayás Manuel, Dogonadze Marine, Lavrova Anastasia, Molina-Sejas Jorge, Tadesse Michaël, Xulvi-Brunet Ramón, Cox Jonathan A G, Nerukh Dmitry, González-Benítez Natalia, Stich Michael
Abstract excerpt
The mutation S315T of the catalase-peroxidase (CP) protein KatG of Mycobacterium tuberculosis is the most common mutation that confers resistance to the prodrug isoniazid. Here, we reconstruct its evolutionary history in 145 whole-genome sequences of M. tuberculosis from Russian hospitals, inferring 11 independent appearances of this mutation and 5 reversion events, with an estimated reversion rate 1,500 times...
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