Article
[A pharmacogenetic analysis of dopaminergic and opioidergic genes in opioid addicts treated with the combination of naltrexone and guanfacine].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2000
Kibitov А О, Krupitsky Е М, Blokhina Е А, Verbitskaya Е V, Brodyansky V М, Alekseeva N P, Bushara N М, Yaroslavtseva Т S, Palatkin V Yа, Masalov D V, Burakov А М, Romanova Т N, Sulimov G Yu, Grinenko A Yа, Kosten Т, Nielsen D, Zvartau E E
Abstract excerpt
AIM: To evaluate an effect of opioid receptor and dopamine system gene polymorphisms on the efficacy of combined treatment with oral naltrexone and guanfacine in a randomized double blinded double dummy placebo controlled clinical trial. MATERIAL AND METHODS: Three hundred and one patients with opioid dependence were randomized into 4 treatment groups: naltrexone 50 mg/day + guanfacine 1 mg/day (N+G); naltrexone...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.