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Article

Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2010

Bishop Matthew T, Will Robert G, Manson Jean C

Abstract excerpt

The biological determinants of the phenotypic variation in sporadic Creutzfeldt-Jakob disease (sCJD) are unknown. To categorize sCJD cases, the prion protein (PrP) codon 129 genotype and the biochemical characteristics of the disease-associated form of PrP (PrP(Sc)) can be combined to form six subgroups (MM1, MM2, MV1, MV2, VV1, and VV2). This classification largely correlates with the known variation in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20547859
DOI: 10.1073/pnas.1004688107
PMCID: PMC2900653

Genes

PRNP

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