Article
Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease.
Annals of neurology - 1 Jun 1996
Parchi P, Castellani R, Capellari S, Ghetti B, Young K, Chen S G, Farlow M, Dickson D W, Sima A A, Trojanowski J Q, Petersen R B, Gambetti P
Abstract excerpt
We sequenced the prion protein gene and studied the biochemical characteristics and the intracerebral distribution of protease-resistant prion protein with Western blot and immunohistochemistry in 19 cases of sporadic Creutzfeldt-Jakob disease. We identified four groups of subjects defined by the genotype at codon 129 of the prion protein gene, the site of a common methionine/valine polymorphism, and two types of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.