Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.

doi:10.1038/383685a0

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Article

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.

Nature - 24 Oct 1996

Collinge J, Sidle K C, Meads J, Ironside J, Hill A F

Abstract excerpt

Strains of transmissible spongiform encephalopathies are distinguished by differing physicochemical properties of PrPSc, the disease-related isoform of prion protein, which can be maintained on transmission to transgenic mice. 'New variant' Creutzfeldt-Jakob disease (CJD) has strain characteristi...

Topics

Animals
Cats
Creutzfeldt-Jakob Syndrome
Encephalopathy, Bovine Spongiform
Endopeptidase K
Genetic Variation
Glycosylation
Growth Hormone
Humans
Macaca
Mice
Mice, Inbred C57BL
Mice, Transgenic
PrPC Proteins
PrPSc Proteins
Prions
Protein Conformation

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