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Article

Noninvasive Identification of Isocitrate Dehydrogenase 1/2 Mutation in Brainstem Gliomas.

JCO precision oncology - 1 Jan 2026

Kushnirsky Marina, Lin Andrew L, Bale Tejus, Moss Nelson S, Rosenblum Marc, Sait Sameer Farouk, Schaff Lauren R, Gavrilovic Igor T, Pentsova Elena, Grommes Christian, Meng Alicia, Imber Brandon, Tabar Viviane, Yu Kenny Kwok Hei, Miller Alexandra, Malani Rachna, Karajannis Matthias A, Mellinghoff Ingo, Young Robert J, Thakur Sunitha

Abstract excerpt

PURPOSE: A subset of brainstem gliomas harbor an isocitrate dehydrogenase 1/2 (IDH1/2) mutation, which has important prognostic and treatment implications. We evaluated the radiographic features and the sensitivity of magnetic resonance spectroscopy (MRS) and cerebrospinal fluid cell-free DNA (CSF cfDNA) sequencing at detecting IDH1/2 mutations in a cohort of these tumors. METHODS: We identified IDH-mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41740066
DOI: 10.1200/PO-25-00859
PMCID: PMC13399720

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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