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Article

Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine.

Human genetics - 1 Apr 2017

Haralambieva Iana H, Ovsyannikova Inna G, Kennedy Richard B, Larrabee Beth R, Zimmermann Michael T, Grill Diane E, Schaid Daniel J, Poland Gregory A

Abstract excerpt

Population-based studies have revealed 2-10% measles vaccine failure rate even after two vaccine doses. While the mechanisms behind this remain unknown, we hypothesized that host genetic factors are likely to be involved. We performed a genome-wide association study of measles specific neutralizing antibody and IFNγ ELISPOT response in a combined sample of 2872 subjects. We identified two distinct chromosome 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28289848
DOI: 10.1007/s00439-017-1768-9
PMCID: PMC5433429

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