Article
The association of CD46, SLAM and CD209 cellular receptor gene SNPs with variations in measles vaccine-induced immune responses: a replication study and examination of novel polymorphisms.
Human heredity - 1 Jan 2011
Ovsyannikova Inna G, Haralambieva Iana H, Vierkant Robert A, O'Byrne Megan M, Jacobson Robert M, Poland Gregory A
Abstract excerpt
BACKGROUND: The measles virus (MV) interacts with two known cellular receptors: CD46 and SLAM. The transmembrane receptor CD209 interacts with MV and augments dendritic cell infection. METHODS: 764 subjects previously immunized with measles-mumps-rubella vaccine were genotyped for 66 candidate SNPs in the CD46, SLAM and CD209 genes as part of a larger study. RESULTS: A previously detected association of the CD46...
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