Article
Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production.
Nature communications - 1 Jan 2014
Blazeck John, Hill Andrew, Liu Leqian, Knight Rebecca, Miller Jarrett, Pan Anny, Otoupal Peter, Alper Hal S
Abstract excerpt
Economic feasibility of biosynthetic fuel and chemical production hinges upon harnessing metabolism to achieve high titre and yield. Here we report a thorough genotypic and phenotypic optimization of an oleaginous organism to create a strain with significant lipogenesis capability. Specifically, we rewire Yarrowia lipolytica's native metabolism for superior de novo lipogenesis by coupling combinatorial...
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