Article
A microRNA family exerts maternal control on sex determination in C. elegans.
Genes & development - 15 Feb 2017
McJunkin Katherine, Ambros Victor
Abstract excerpt
Gene expression in early animal embryogenesis is in large part controlled post-transcriptionally. Maternally contributed microRNAs may therefore play important roles in early development. We elucidated a major biological role of the nematode mir-35 family of maternally contributed essential microRNAs. We show that this microRNA family regulates the sex determination pathway at multiple levels, acting both...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Embryonic Development
- Female
- Gene Expression Regulation, Developmental
- Male
- MicroRNAs
- Mutation
- RNA-Binding Proteins
- Sex Determination Processes