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Article

miRNAs cooperate in apoptosis regulation during C. elegans development.

Genes & development - 15 Jan 2017

Sherrard Ryan, Luehr Sebastian, Holzkamp Heinke, McJunkin Katherine, Memar Nadin, Conradt Barbara

Abstract excerpt

Programmed cell death occurs in a highly reproducible manner during Caenorhabditis elegans development. We demonstrate that, during embryogenesis, miR-35 and miR-58 bantam family microRNAs (miRNAs) cooperate to prevent the precocious death of mothers of cells programmed to die by repressing the gene egl-1, which encodes a proapoptotic BH3-only protein. In addition, we present evidence that repression of egl-1 is...

Topics

Animals
Apoptosis
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Lineage
Embryo, Nonmammalian
Gene Expression Regulation, Developmental
MicroRNAs
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28167500
DOI: 10.1101/gad.288555.116
PMCID: PMC5322734

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