Article
Immunoregulation of Dendritic Cell Subsets by Inhibitory Receptors in Urothelial Cancer.
European urology - 1 Jun 2017
Chevalier Mathieu F, Bohner Perrine, Pieraerts Claire, Lhermitte Benoit, Gourmaud Jolanta, Nobile Antoine, Rotman Samuel, Cesson Valerie, Martin Virginie, Legris Anne-Sophie, Dartiguenave Florence, Gharbi Dalila, De Leval Laurence, Speiser Daniel E, Nardelli-Haefliger Denise, Jichlinski Patrice, Derré Laurent
Abstract excerpt
Blockade of inhibitory receptors (IRs) overexpressed by T cells can activate antitumor immune responses, resulting in the most promising therapeutic approaches, particularly in bladder cancer, currently able to extend patient survival. Thanks to their ability to cross-present antigens to T cells, dendritic cells (DCs) are an immune cell population that plays a central role in the generation of effective antitumor...
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