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Article

Post-transcriptional down-regulation of Toll-like receptor signaling pathway in umbilical cord blood plasmacytoid dendritic cells.

Cellular immunology - 1 Jan 2000

Charrier Emily, Cordeiro Paulo, Cordeau Martine, Dardari R'Kia, Michaud Annie, Harnois Michaël, Merindol Natacha, Herblot Sabine, Duval Michel

Abstract excerpt

Plasmacytoid dendritic cells (PDCs) from human umbilical cord blood (UCB) produce lower amounts of IFN-α upon TLR stimulation compared with adult counterparts. This difference may play a role in the low graft-versus-host disease rate after UCB transplantation and in the impaired immune response of the neonate to pathogens. Comparing UCB PDC to their adults counterparts, we found that they exhibited a mature...

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Source

Identifiers

PMID: 22578600
DOI: 10.1016/j.cellimm.2012.04.010

Genes

PDC
IRAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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