Article
Associations between period 3 gene polymorphisms and sleep- /chronotype-related variables in patients with late-life insomnia.
Chronobiology international - 1 Jan 2017
Mansour Hader A, Wood Joel, Chowdari Kodavali V, Tumuluru Divya, Bamne Mikhil, Monk Timothy H, Hall Martica H, Buysse Daniel J, Nimgaonkar Vishwajit L
Abstract excerpt
A variable number tandem repeat polymorphism (VNTR) in the period 3 (PER3) gene has been associated with heritable sleep and circadian variables, including self-rated chronotypes, polysomnographic (PSG) variables, insomnia and circadian sleep-wake disorders. This report describes novel molecular and clinical analyses of PER3 VNTR polymorphisms to better define their functional consequences. As the PER3 VNTR is...
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