Dissecting the genetic architecture of circadian rhythms in human tissues using a quantitative circadian deviation score.

doi:10.1186/s13059-025-03767-4

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Article

Dissecting the genetic architecture of circadian rhythms in human tissues using a quantitative circadian deviation score.

Genome biology - 25 Sept 2025

Li Zheyu, Chen Liang

Abstract excerpt

BACKGROUND: Circadian rhythms influence various physiological and behavioral processes, including sleep, metabolism, and immune response. Although key regulatory factors of biological clocks have been identified and genome-wide association studies have pinpointed some genetic variants linked to s...

Topics

Humans
Circadian Rhythm
Polymorphism, Single Nucleotide
Male
Female
Genome-Wide Association Study
Quantitative Trait Loci
Organ Specificity

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