Article
A common polymorphism near PER1 and the timing of human behavioral rhythms.
Annals of neurology - 1 Sept 2012
Lim Andrew S P, Chang Anne-Marie, Shulman Joshua M, Raj Towfique, Chibnik Lori B, Cain Sean W, Rothamel Katherine, Benoist Christophe, Myers Amanda J, Czeisler Charles A, Buchman Aron S, Bennett David A, Duffy Jeanne F, Saper Clifford B, De Jager Philip L
Abstract excerpt
OBJECTIVE: Circadian rhythms influence the timing of behavior, neurological diseases, and even death. Rare mutations in homologs of evolutionarily conserved clock genes are found in select pedigrees with extreme sleep timing, and there is suggestive evidence that certain common polymorphisms may be associated with self-reported day/night preference. However, no common polymorphism has been associated with the...
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