Article
[Phenotypic screens or one stone to kill two birds: discover the target and its pharmacological regulator].
Medecine sciences : M/S - 1 Oct 2013
Prudent Renaud, Soleilhac Emmanuelle, Barette Caroline, Fauvarque Marie-Odile, Lafanechère Laurence
Abstract excerpt
Phenotypic screens, in which chemical libraries are assayed on cells with the aim to isolate compounds that interfere with a given cell function, are a risky but powerful strategy to discover, in the same approach, new therapeutic targets and the compounds able to regulate them. With a strong experience of nearly 10 years in the field, we present the advantages of such an approach, the possible troubles and...
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