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Article

Structural systems pharmacology: a new frontier in discovering novel drug targets.

Current drug targets - 1 Aug 2013

Tan Hepan, Ge Xiaoxia, Xie Lei

Abstract excerpt

The modern target-based drug discovery process, characterized by the one-drug-one-gene paradigm, has been of limited success. In contrast, phenotype-based screening produces thousands of active compounds but gives no hint as to what their molecular targets are or which ones merit further research. This presents a question: What is a suitable target for an efficient and safe drug? In this paper, we argue that...

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Identifiers

PMID: 23597016
DOI: 10.2174/1389450111314090003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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