Article
Cystic fibrosis-related diabetes is caused by islet loss and inflammation.
JCI insight - 19 Apr 2018
Hart Nathaniel J, Aramandla Radhika, Poffenberger Gregory, Fayolle Cody, Thames Ariel H, Bautista Austin, Spigelman Aliya F, Babon Jenny Aurielle B, DeNicola Megan E, Dadi Prasanna K, Bush William S, Balamurugan Appakalai N, Brissova Marcela, Dai Chunhua, Prasad Nripesh, Bottino Rita, Jacobson David A, Drumm Mitchell L, Kent Sally C, MacDonald Patrick E, Powers Alvin C
Abstract excerpt
Cystic fibrosis-related (CF-related) diabetes (CFRD) is an increasingly common and devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the underlying causes of CFRD are unclear. Here, we examined cystic fibrosis transmembrane conductance regulator (CFTR) islet expression and whether the CFTR participates in islet endocrine cell function using murine models of β cell CFTR...
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