Article

MiRNA-200b-3p represses LRH-1 expression and is associated with reduced serum bile acid in human obstructive cholestasis

2020-03-13

Abstract excerpt

<h4>Background: </h4> MicroRNAs are closely associated with liver diseases including cholestasis, but the roles of miR-200 family in cholestasis has not been determined. Liver receptor homolog-1 (LRH-1/NR5A2) plays an important role in maintaining bile acid homeostasis by regulating some genes, including CYP7A1 and CYP8B1, but the mechanistic details remain to be elucidated in human cholestasis. Methods The mRNA a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3527ffd7-39ff-54e3-a3f1-9a8991c447b9
DOI: 10.21203/rs.3.rs-17197/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiRNA-200b-3p represses LRH-1 expression and is associated with reduced serum bile acid in human obstructive cholestasisDOI 10.21203/rs.3.rs-17197/v1Read

Identification of a potential miRNA-mRNA regulatory network associated with the pathogenesis of cholestatic liver diseasesSemantic proximity Read

Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expressionSemantic proximity Read

Transcriptional Regulation of the Human Sterol 12α-Hydroxylase Gene (CYP8B1)Semantic proximity Read

MicroRNAs and cholestatic liver diseases.Semantic proximity Read

Bile acid synthesis disorders in Japan: long-term outcome and chenodeoxycholic acid treatmentSemantic proximity Read

RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expressionSemantic proximity Read

Integrated analysis of differential lncRNA and mRNA expression in cholelithiasis based on high-throughput sequencing and bioinformaticsSemantic proximity Read

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoterSemantic proximity Read

MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expressionSemantic proximity Read

Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell linesSemantic proximity Read

Bile Acid Synthesis Disorders in Japan: Long-Term Outcome and Chenodeoxycholic Acid Treatment.Semantic proximity Read

Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuRSemantic proximity Read