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Article

TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin.

Journal of immunology research - 1 Jan 2017

Khalifa Olfa, Balandraud Nathalie, Lambert Nathalie, Auger Isabelle, Roudier Jean, Sénéchal Audrey, Geneviève David, Picard Christophe, Lefranc Gérard, Touitou Isabelle, Mrenda Bakridine M'Madi, Benedito Cécilia, Pardoux Etienne, Gagez Anne-Laure, Pers Yves-Marie, Jorgensen Christian, Mahjoub Touhami, Apparailly Florence

Abstract excerpt

Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n = 408) compared with...

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Share to Arthritis, Rheumatoid
Share to Chromosomes, Human, X
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Share to HLA-DR Antigens
Share to HLA-DRB1 Chains
Share to Interleukin-1 Receptor-Associated Kinases
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Source

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Identifiers

PMID: 28271077
DOI: 10.1155/2017/4915950
PMCID: PMC5320318

Genes

IRAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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