Association study of human leukocyte antigen-DRB1 alleles with rheumatoid arthritis in south Tunisian patients.

doi:10.1007/s10067-012-1954-z

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Article

Association study of human leukocyte antigen-DRB1 alleles with rheumatoid arthritis in south Tunisian patients.

Clinical rheumatology - 1 Jun 2012

Ben Hamad Mariem, Mahfoudh Nadia, Marzouk Sameh, Kammoun Arwa, Gaddour Lilia, Hakim Faiza, Fakhfakh Faiza, Bahloul Zouheir, Makni Hafedh, Maalej Abdellatif

Abstract excerpt

The aim of this study is to explore relationship between HLA-DRB1 alleles and the susceptibility and clinical features of rheumatoid arthritis (RA) in the south Tunisian population. We studied 142 RA patients and 123 controls matched for age, sex, and ethnicity. HLA-DRB1 genotyping and HLA-DRB1*04 subtypes were performed using polymerase chain reaction/sequence-specific primers. Association was assessed based on...

Topics

Adult
Alleles
Arthritis, Rheumatoid
Autoantibodies
DNA Primers
Female
Gene Frequency
Genotype
HLA-DRB1 Chains
Humans
Male
Polymerase Chain Reaction
Rheumatology
Tunisia

Source

Open in PubMed

Identifiers

PMID: 22349877
DOI: 10.1007/s10067-012-1954-z

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