Article

Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells

2021-11-29

Abstract excerpt

It is questionable why no further experimental evidence confirming those findings, since being reported by Manning’s group in 2014’s Nature (doi: 10.1038/nature13492), has been provided in the hitherto known literature. They found that ‘Growth factors stimulate an increase in Nrf1 through mTORC1, which induces NRF1 transcription in an SREBP1-dependent manner’ and asserted that Nrf1 is directly regulated by SREBP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e6c3cf6-0b25-5272-b88d-9c323eccfbf0
DOI: 10.1101/2021.11.29.470338

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cellsDOI 10.1101/2021.11.29.470338Read

Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseasesSemantic proximity Read

Nrf2/ARE axis signalling in hepatocyte cellular deathSemantic proximity Read

Translational Regulation in Hepatocellular CarcinogenesisSemantic proximity Read

Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species (ROS) in human hepatoma cells, which is alleviated by 2-bromopalmitateSemantic proximity Read

Integrated stress response in hepatitis C promotes Nrf2-related chaperone-mediated autophagy: A novel mechanism for host-microbe survival and HCC development in liver cirrhosisSemantic proximity Read

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integritySemantic proximity Read

Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinomaSemantic proximity Read

NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegalySemantic proximity Read

Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor RepressorSemantic proximity Read

Different inhibition of Nrf2 by two Keap1 isoforms α and β to shape malignant behaviour of human hepatocellular carcinomaSemantic proximity Read

An important role of SREBP-1 in HBV and HCV co-replication inhibition by PTENSemantic proximity Read

Role of early growth response 1 in liver metabolism and liver cancerSemantic proximity Read