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Article

HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus

19 Feb 2017

Abstract excerpt

Flaviviral infections including dengue virus are an increasing clinical problem worldwide. Dengue infection triggers host production of the type 1 IFN, IFN alpha, one of the strongest and broadest acting antivirals known. However, dengue virus subverts host IFN signaling at early steps of IFN signal transduction. This subversion allows unbridled viral replication which subsequently triggers ongoing production of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28265266
DOI: 10.3389/fmicb.2017.00240

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