Article
Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44.
PloS one - 1 Jan 2017
Wessels Deborah, Lusche Daniel F, Voss Edward, Kuhl Spencer, Buchele Emma C, Klemme Michael R, Russell Kanoe B, Ambrose Joseph, Soll Benjamin A, Bossler Aaron, Milhem Mohammed, Goldman Charles, Soll David R
Abstract excerpt
Using unique computer-assisted 3D reconstruction software, it was previously demonstrated that tumorigenic cell lines derived from breast tumors, when seeded in a 3D Matrigel model, grew as clonal aggregates which, after approximately 100 hours, underwent coalescence mediated by specialized cells, eventually forming a highly structured large spheroid. Non-tumorigenic cells did not undergo coalescence. Because...
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