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Differentiation States of Phenotypic Transition of Melanoma Cells Are Revealed by 3D Cell Cultures.

Cells - 17 Jan 2024

Fontana Fabrizio, Sommariva Michele, Anselmi Martina, Bianchi Francesca, Limonta Patrizia, Gagliano Nicoletta

Abstract excerpt

Melanoma is characterized by high metastatic potential favored by the epithelial-to-mesenchymal transition (EMT), leading melanoma cells to exhibit a spectrum of typical EMT markers. This study aimed to analyze the expression of EMT markers in A375 and BLM melanoma cell lines cultured in 2D monolayers and 3D spheroids using morphological and molecular methods. The expression of EMT markers was strongly affected...

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Identifiers

PMID: 38247872
DOI: 10.3390/cells13020181
PMCID: PMC10814891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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