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Article

Pleiotropic genes in psychiatry: Calcium channels and the stress-related FKBP5 gene in antidepressant resistance.

Progress in neuro-psychopharmacology & biological psychiatry - 2 Feb 2018

Fabbri Chiara, Corponi Filippo, Albani Diego, Raimondi Ilaria, Forloni Gianluigi, Schruers Koen, Kasper Siegfried, Kautzky Alexander, Zohar Joseph, Souery Daniel, Montgomery Stuart, Cristalli Carlotta Pia, Mantovani Vilma, Mendlewicz Julien, Serretti Alessandro

Abstract excerpt

A candidate gene and a genome-wide approach were combined to study the pharmacogenetics of antidepressant response and resistance. Investigated genes were selected on the basis of pleiotropic effect across psychiatric phenotypes in previous genome-wide association studies and involvement in antidepressant response. Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28989100
DOI: 10.1016/j.pnpbp.2017.10.005

Genes

TRD
FKBP5
ANK3
CACNB2
GRM7
ITIH3
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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