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DELETIONS OF CHROMOSOME 20q AND THE PATHOGENESIS OF MYELOPROLIFERATIVE DISORDERS

1 Nov 1996

Abstract excerpt

Myeloproliferative disorders (MPD) and myelodysplastic syndromes (MDS) represent an overlapping spectrum of clonal preleukaemic conditions in which mutations have resulted in dysregulation of multipotent haemopoietic progenitors. An interstitial deletion of the long arm of chromosome 20 is a recurring abnormality associated with both of these classes of disorders. The association of 20q deletions with 'stem cell'...

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Identifiers

PMID: 8904873
DOI: 10.1046/j.1365-2141.1996.d01-1896.x

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Related research

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Research trail→

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DELETIONS OF CHROMOSOME 20q AND THE PATHOGENESIS OF MYELOPROLIFERATIVE DISORDERSPMID 8904873Read ↗

Chromosome 20 deletions in myelodysplastic syndromes and Philadelphia-chromosome-negative myeloproliferative disorders: characterization by molecular cytogenetics of commonly deleted and retained regionsSemantic proximity Read ↗

Hematologic Disorders Associated With Deletions of Chromosome 20q:A Clinicopathologic Study of 107 PatientsSemantic proximity Read ↗

Chromosome 20 deletions in myeloid malignancies: reduction of the common deleted region, generation of a PAC/BAC contig and identification of candidate genesSemantic proximity Read ↗

Refinement of the commonly deleted segment in myeloid leukemias with a del(20q).Semantic proximity Read ↗

Molecular genetics of myeloid leukemia: identification of the commonly deleted segment of chromosome 20.Semantic proximity Read ↗

Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders.Semantic proximity Read ↗

Mosaic chromosome 20q deletions are more frequent in the aging populationSemantic proximity Read ↗

Characteristics and outcome of myelodysplastic syndromes (MDS) with isolated 20q deletion: A report on 62 casesSemantic proximity Read ↗

Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact.Semantic proximity Read ↗

Refinement of the smallest commonly deleted segment of chromosome 20 in malignant myeloid diseases and development of a PAC-based physical and transcription map.Semantic proximity Read ↗

Morphology, cytogenetics, and survival in myelodysplasia with del(20q) or ider(20q): a multicenter studySemantic proximity Read ↗

Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F.Semantic proximity Read ↗

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