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Article

Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response

2 Mar 2017

Abstract excerpt

Interleukin-33 (IL-33) is an alarmin cytokine that binds to the interleukin 1 receptor-like 1 protein ST2. Clock is a key circadian gene that is essential for endogenous clockworks in mammals. This study investigated whether Clock temporally regulated IL-33-mediated responses in mast cells. The kinetics of IL-33-mediated IL-6, IL-13, and TNF-α productions were compared between bone marrow-derived mast cells...

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PMID: 28259547
DOI: 10.1016/j.alit.2017.02.004

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